first_imgEmail Pinterest Share on Twitter Depression is a major public health burden, affecting millions of people worldwide and costing the US alone over $200 billion per year. The most common treatments for depression are cognitive behaviour therapy (CBT) and antidepressants. However, 1 in 5 patients with depression do not respond to any intervention, and many relapse.“Previous animal and human brain imaging studies have suggested that psilocybin may have effects similar to other antidepressant treatments,” says Professor David Nutt, senior author from Imperial College London “Psilocybin targets the serotonin receptors in the brain, just as most antidepressants do, but it has a very different chemical structure to currently available antidepressants and acts faster than traditional antidepressants.” [1]The trial involved 12 patients (6 women, 6 men) with moderate to severe depression (average length of illness was 17.8 years). The patients were classified as having treatment-resistant depression, having previously had two unsuccessful courses of antidepressants (lasting at least 6 weeks). Most (11) had also received some form of psychotherapy. Patients were not included if they had a current or previous psychotic disorder, an immediate family member with a psychotic disorder, history of suicide or mania or current drug or alcohol dependence.Patients attended two treatment days – a low (test) dose of psilocybin 10mg oral capsules, and a higher (therapeutic) dose of 25mg a week later. Patients took the capsules while lying down on a ward bed, in a special room with low lighting and music, and two psychiatrists sat either side of the bed. The psychiatrists were present to provide support and check in on patients throughout the process by asking how they were feeling. Patients had an MRI scan the day after the therapeutic dose. They were followed up one day after the first dose, and then at 1, 2, 3, and 5 weeks and 3 months after the second dose (figure 1).The psychedelic effects of psilocybin were detectable 30 to 60 minutes after taking the capsules. The psychedelic effect peaked at 2-3 hours, and patients were discharged 6 hours later. No serious side effects were reported, and expected side effects included transient anxiety before or as the psilocybin effects began (all patients), some experienced confusion (9), transient nausea (4) and transient headache (4). Two patients reported mild and transient paranoia.At 1 week post-treatment, all patients showed some improvement in their symptoms of depression. 8 of the 12 patients (67%) achieved temporary remission. By 3 months, 7 patients (58%) continued to show an improvement in symptoms and 5 of these were still in remission. Five patients showed some degree of relapse (figure 4).The patients knew they were receiving psilocybin (an ‘open-label’ trial) and the effect of psilocybin was not compared with a placebo. The authors also stress that most of the study participants were self-referred meaning they actively sought treatment, and may have expected some effect (5 had previously tried psilocybin before, table 1). All patients had agreement from their GP to take part in the trial. They add that patients were carefully screened and given psychological support before, during and after the intervention, and that the study took place in a positive environment. Further research is now needed to tease out the relative influence of these factors on symptoms of depression, and look at how psilocybin compares to placebo and other current treatments.Writing in a linked Comment, Professor Philip Cowen, MRC Clinical Scientist, University of Oxford, Oxford, UK, says: “The key observation that might eventually justify the use of a drug like psilocybin in treatment-resistant depression is demonstration of sustained benefit in patients who previously have experienced years of symptoms despite conventional treatments, which makes longer-term outcomes particularly important. The data at 3 month follow-up (a comparatively short time in patients with extensive illness duration) are promising but not completely compelling, with about half the group showing significant depressive symptoms. Further follow-ups using detailed qualitative interviews with patients and family could be very helpful in enriching the assessment.” Psilocybin – a hallucinogenic compound derived from magic mushrooms – may offer a possible new avenue for antidepressant research, according to a new study published in The Lancet Psychiatry today.The small feasibility trial, which involved 12 people with treatment-resistant depression, found that psilocybin was safe and well-tolerated and that, when given alongside supportive therapy, helped reduce symptoms of depression in about half of the participants at 3 months post-treatment. The authors warn that strong conclusions cannot be made about the therapeutic benefits of psilocybin but the findings show that more research in this field is now needed.“This is the first time that psilocybin has been investigated as a potential treatment for major depression,” says lead author Dr Robin Carhart-Harris, Imperial College London, London, UK. “Treatment-resistant depression is common, disabling and extremely difficult to treat. New treatments are urgently needed, and our study shows that psilocybin is a promising area of future research. The results are encouraging and we now need larger trials to understand whether the effects we saw in this study translate into long-term benefits, and to study how psilocybin compares to other current treatments.” [1]center_img Share on Facebook Share LinkedInlast_img read more

first_imgBritish Columbia measles outbreak spreadsA measles outbreak in the Fraser Valley east of Vancouver has temporarily closed a school in eastern British Columbia after sickening nearly 100 students, and vaccine is being distributed to pharmacies and physicians’ offices as the outbreak spreads from the school into the nearby communities, according to news sources this week.The outbreak began at the Mount Cheam Christian School in the town of Chilliwack, said a Mar 11 Toronto Star story. Two cases in the greater community had been confirmed at that time, but a CBC News story today says 80 new cases have been reported from Chilliwack and nearby Agassiz. One patient, a 9-year-old girl, has been hospitalized.British Columbia’s Fraser Health system is requesting that older children and adults in its Fraser East region (which includes the communities of Abbotsford, Mission, Harrison Hot Springs, and Hope in addition to Chilliwack and Agassiz) get vaccinated with the two-dose series, according to a news story from the organization. Children under age 5, who are at greatest risk from measles, need to obtain vaccinations through a physician’s office or public health clinic, says Fraser.The Star story says the students at the school had a low vaccination rate because of religious beliefs, but of even more concern is the 25% to 30% of people in the surrounding communities who have not been vaccinated even though the vaccine is available and free.Fraser is organizing vaccination clinics in Chilliwack and Agassiz for next week. In addition, people are being asked to isolate themselves at home if they have measles symptoms (blotchy rash, high fever, runny nose, cough), to avoid travel during spring break if they think they may have been exposed, and to alert any healthcare facility they plan to visit.Mar 14 CBC News story Mar 13 Fraser Health news story Mar 11 Toronto Star reportIn related news, California is reporting 32 cases of measles since the beginning of the year, according to a news release today from the California Department of Public Health (CDPH). Last year at this time, only 3 cases had been reported.Vaccination coverage in the state is high; 10 of the cases reported this year have been in people who have traveled to other countries where measles outbreaks are ongoing or where it is endemic (Philippines, India, and Vietnam). Mar 14 CDPH news releaseMore measles cases confirmed on Mediterranean cruise shipItalian and European health officials yesterday in Eurosurveillance said 15 more cases of measles have been confirmed aboard a Mediterranean cruise ship that has posed a cross-border health threat. The outbreak was originally announced in a Mar 5 risk assessment from the European Centre for Disease Prevention and Control (ECDC).As of Mar 11, 27 measles cases have been reported, 21 of them in crew members and 4 in passengers. The crew or passenger status couldn’t be determined for two of the patients. Of the total, 22 cases were lab-confirmed and 5 were classified as probable. In its Mar 5 risk assessment, the ECDC had said 7 cases were confirmed at that point.Ages range from 1 year to 42 years, and 21 of the case-patients are male. Home countries were known for 19 of the patients and included Italy, India, Philippines, Honduras, Austria, Brazil, and Indonesia.Of 12 cases in which vaccination history was available, 3 patients were vaccinated with one or two doses and 9 were unvaccinated. Among samples obtained from 22 patients, measles genotype B3 was found in 10 and the samples were 100% identical to each other, suggesting a common origin; the strain was related to two British strains identified in February.Illness onset ranged from Feb 20 through Mar 1. European countries received lists of passenger names and passport numbers for those who were aboard the cruise, but in some instances there wasn’t enough contact information to track some of travelers.On Feb 27 the ship’s medical team launched a vaccination campaign for crew and passengers who had no evidence or prior immunity. The ship is also offering vaccination to new crew members who arrive on board.The authors of the report said measles aboard a cruise ship presents many challenges, including a large number of people in close quarters with unknown vaccination status. They noted that no new infections have been seen in the crew since Feb 27, but some may already have been incubating measles when they were vaccinated. The number of infected passengers may be underestimated, because the average time spend on board wasn’t long enough for an exposed patient to develop symptoms.Mar 13 Eurosurveill report Mar 5 CIDRAP News story “ECDC reports measles outbreak on cruise ship” Study: Pertussis vaccine linked to fewer hospitalizationsEven though a high proportion of breakthrough pertussis cases occur in people vaccinated for the disease, immunization does result in decreased morbidity, including hospitalizations, according to a study today in Clinical Infectious Diseases.The authors analyzed the records for 624 children in the Portland, Ore., area aged 6 weeks to 18 years with confirmed pertussis from 2010 to 2012 to determine vaccination status and disease severity and duration. They found that 286 (45%) patients were up to date with federal vaccination recommendations and 167 (27%) had received one or more vaccinations but were not up to date.Ever-vaccinated patients had significantly lower risks of hospitalization and of severe disease than unvaccinated patients. They also had decreased odds of hospitalization and of developing pneumonia compared with those unvaccinated.Furthermore, patients who were up to date with federal recommendations had a significantly shorter duration of coughing, a measure of disease severity.An accompanying commentary stressed the need for a new pertussis vaccine since the current ones allow so many breakthrough infections. However, it concludes, “The current vaccines, even with the limitations, are still protective and reduce the severity of pertussis.” Mar 14 Clin Infec Dis study abstract Mar 14 Clin Infec Dis commentary landing pagelast_img read more

first_imgGOP Chairman Steve Pearce New Mexico GOP News:ALBUQUERQUE — Republican Party of New Mexico Chairman Steve Pearce released the following statement in response to today’s announcement from the U.S. Forest Service lifting the suspension of sales of fuelwood permits:“Today’s announcement lifting the suspension of fuelwood permits only addresses one of the four main problems created by the U.S. district court judge who made a ruling against the U.S. Forest Service and the U.S. Fish and Wildlife Service. The ruling continues to kill jobs New Mexico desperately needs, puts our wonderful forests more at risk of being destroyed by fire, disease or pests and makes the habitat worse when forests are  not maintained.“The best laboratory to compare habitats for spotted owls is where the Mescalero Forest which has been thinned joins the Lincoln National Forest which has not been thinned. The spotted owls are moving from the U.S. forests to the thinned areas.“I will continue to work with the U.S. Department of Agriculture to ensure the suspensions are resolved. I have asked USDA to file an appeal as soon as possible and to review the defense submitted to the court by the N.M Director of the United States Forest Service. I have also asked Secretary Perdue and other agency officials to visit N.M. to review the situation.”last_img read more

first_imgMetzger’s General Manager David Jolly in front of the Los Alamos store Tuesday is the recipient of the prestigious International Economic Development Council’s 2020 Citizen Leadership Award. Photo by John McHale/ladailypost.com By CAROL A. CLARKLos Alamos Daily Postcaclark@ladailypost.comMetzger’s Do It Best Hardware General Manager David Jolly was selected as the recipient of the prestigious 2020 Citizen Leadership Award from the International Economic Development Council (IEDC).Los Alamos Commerce and Development Corporation (LACDC), along with Los Alamos MainStreet and the Chamber of Commerce announced the award Tuesday.“LACDC is thrilled to see Dave recognized by the IEDC for his continuous devotion to economic development in Los Alamos County,” Sullivan said. “This is a prestigious award and Dave is truly deserving of it. I’d like to ask the community to join LACDC in congratulating Dave and thank him for all the great work he does.”The IEDC is the largest association for professional economic developers in the world and has recognized 19 leaders in the field with its 2020 Honorary & Leadership awards for achieving excellence in the profession. Nominees for these individual awards were selected through a several month-long process and from a pool of many highly qualified nominees.Chamber Director Ryn Herrmann put together the information to nominate Jolly for this important award.“David does so much for the community of Los Alamos. He plays a key leadership role in local economic development by often going above and beyond his duties for the various committees and boards he has served on,” Herrmann said. “David is one of the most committed community advocates I have had the pleasure of working with. We were delighted to nominate David for the IEDC Citizen Leadership Award and thrilled that he won!”IEDC’s Excellence in Economic Development Awards recognize the world’s best economic development programs and partnerships, marketing materials, and the year’s most influential leaders. These awards honor organizations and individuals for their efforts in creating positive change in urban, suburban and rural communities.The Citizen Leadership Award recognizes Jolly as a community and business leader who plays a key leadership role in economic development. Metzger’s Hardware has been a staple of Los Alamos for more than 70 years and plays a large part in the Los Alamos community as one of the anchor downtown businesses.Jolly has served as general manager for more than 10 years and has taken on many key leadership roles. He has the reputation for genuinely caring about his customers and about Los Alamos, often going above and beyond his roles in the various committees and boards he has served on by meeting one-on-one with business owners, economic development professionals and others.“I believe a strong business depends on a strong community, so to me, working to build the community comes back to the company in increased business. In Los Alamos, the more we can do to offer choices locally so our residents don’t feel the need to go off the hill, the more all of our businesses will benefit,” Jolly said. “I’m fortunate that the Metzgers, Lee and now Greg, feel the same way and have been very supportive. Our philosophies about success in this business have been very much in sync. In fact, that’s one of the things that brought me here 11 years ago.”Metzger’s has been part of the local community since 1947 and Jolly attributes the company’s continued success to the community’s support.“We’re not part of a chain, Metzger’s is a Los Alamos business. That’s why we included the Los Alamos County logo as part of our 70th anniversary logo,” Jolly said. “I like to think we run a first-rate business, and that’s been recognized – from the Facebook comments we get from customers to industry recognition like being named New Mexico’s Hardware SuperStar by HBS Dealer Magazine. This IECD award is especially gratifying though because it comes from outside the industry. I’m really touched that Ryn from the Chamber, Patrick from the LACDC and Lauren McDaniel from MainStreet think enough of what I try to do here to submit the nomination. That’s what counts to me … because they are the ones who do the real work.”Jolly will be honored Oct. 13-16, during a 2020 Virtual Annual Conference.To learn more about IEDC’s Excellence Awards, visit www.iedconline.org/2020Awards.last_img read more

first_imgSubscribe Get instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270.last_img

first_imgSubscribe Get instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270.last_img

first_imgSubscribe now for unlimited access Stay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletters To continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN Get your free guest access  SIGN UP TODAY Subscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our communitylast_img read more

first_imgJacky Line Group was formed in 1988 and has grown into one of the leading freight forwarders in Israel. www.XLProjects.netwww.jackyline.comlast_img

first_imgBuilt in 1975, ENSCO 5002 is a 70 m long and 61 m wide semi-submersible drilling rig, which can accommodate up to 110 people and is capable of drilling up to 10,668 m.The tug Fairmount Expedition hooked-up with the rig offshore Rio de Janeiro before transporting it 9,200 miles to Singapore, via South Africa and Mauritius.  www.fairmount.nlwww.enscoplc.comlast_img

first_imgAfter telling the government, regulators and employers that they have been dodging their responsibilities in tackling workplace sexual harassment for too long, MPs will now examine whether non-disclosure agreements are hiding unlawful discrimination, harassment or abuse at work. The House of Commons women and equalities select committee has today announced it is opening an inquiry examining the wider use of NDAs in cases where any form of harassment or discrimination is alleged, such as pregnancy or maternity discrimination, or racist abuse.Calling for written submissions, the committee, chaired by Maria Miller MP, wants to know how easy it is for employees and employers to access good quality legal advice on NDAs. The committee is asking how quality and the independence of legal advice for employees negotiating severance agreements can be assured when the advice is paid for by the employer.MPs also want to know whether NDAs are more likely to cover particular types of harassment or discrimination. and whether they should be banned or restricted in harassment and discrimination cases.Submissions are being sought on what safeguards should be introduced to prevent misuse, what obligations do employers have to ensure internal grievance procedures, if any, are fair and thorough, do some employers turn to NDAs to repeatedly deal with cases involving a single harasser, and what role should company boards and directors play.Miller said: ‘Use of NDAs in sexual harassment cases is only part of the picture. This new inquiry will focus on their wider use in other cases involving other forms of harassment or discrimination.’The committee, which began looking at sexual harassment in the workplace, has already told regulators to get tougher on solicitors who misuse DNAs to silence victims.Written evidence for the latest inquiry should be submitted by 28 November. The committee says it welcomes evidence from individuals about their experience, but it cannot investigate these cases. Anyone considering making a submission regarding their personal experience of the issues outlined above, and in particular anyone who is subject to an obligation under a NDA, should consider and, where necessary take advice on, their personal circumstances.last_img read more